Bryant Reid Tours The Lowance Center For Human Immunology At Emory

Bryant Reid, The Reid Foundation For Lupus Chair, met with Dr. Ignacio Sanz, Emory Division of Rheumatology Director, and Dr. Frances Lee, Emory Department of Medicine Associate Professor at The Lowance Center for Human Immunology.

The purpose of the Lowance Center for Human Immunology is to understand the immunological and molecular mechanisms responsible for human autoimmune, inflammatory, and allergic diseases. The Lowance Center studies both the innate and adaptive arms of the immune response and the mutual regulation of the two components.

According to the Mayo Clinic, lupus is a disease that occurs when your body’s immune system attacks your own tissues and organs (autoimmune disease). Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart, and lungs. It most often affects people of color, African American, Hispanic, and Asian people.

The importance of the Lowance Center’s research in advancing the understanding of lupus is obvious. The purpose of Mr. Reid’s tour was to provide him with a more in-depth understanding of the scope of work at the Lowance Center and to discuss possible ways The Reid Foundation for Lupus could support or enhance their work.

Dr. Sanz and Dr. Lee provided Mr. Reid with fundamental insights into the depth and scope of lupus research at the Lowance Center. The high ethical standards and transparency of the research at the Center were apparent throughout the tour.
Mentioned was the outstanding work performed by the faculty and in particular Dr. Sam Lim, The Reid Foundation For Lupus Board Member, Drs; Khosroshahi and Williams. Despite its excellent reputation, the Lowrance Center still struggles to find participants to assist them in the research required to understand — or cure –the disease.

The Reid Foundation for Lupus could be an invaluable partner in assisting the Lowance Center in encouraging communities of color to participate in their lupus research studies.

Mr. Reid felt the tour was an important step in building a working relationship between The Reid Foundation for Lupus and other institutions at the forefront of finding effective treatments and, ultimately, a cure for lupus.

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LUPKYNIS Continues to Show Promising Lupus Nephritis Outcomes

The drug treatment, LUPKYNIS® (voclosporin), reduced inflammation and prevented development of kidney damage in people with lupus nephritis (LN, lupus-related kidney disease) over 18 months. Those taking the medication also didn’t exhibit any signs of kidney-related toxicity. LUPKYINS® is a novel, structurally modified calcineurin inhibitor (CNI) that works in two ways – acting as an immunosuppressant through inhibition of T-cell activation and cytokine production, and by promoting podocyte stability in the kidney.

 

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Article Credit: Lupus Foundation of America | lupus.org

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New Study Found People with Lupus Have Unique Oral Bacteria

February 23, 2022
 

In a new study, researchers found people with lupus have a unique mix of oral bacteria, or “microbiome,” that is correlated with disease activity. The oral microbiome is made up of a collection of more than 700 unique bacterial species, and disturbances in the microbiome have been linked to various inflammatory diseases. The findings from this study suggest that specific oral bacteria found in people with lupus could be used as new, non-invasive lupus biomarkers and may serve as a therapeutic target for exploring new treatment options.
 

The oral microbiome is a collection of bacteria that affects the progression of health and disease. To assess whether oral bacteria diversity is linked to lupus, researchers compared the characteristics of the oral microbiome in people with lupus against a healthy control group. They collected and examined tongue coating samples from 255 people with lupus and 280 controls. Compared to the people without lupus, people with lupus had significantly more diverse oral bacteria present on their tongues. Furthermore, people with lupus had higher and lower levels of certain types of bacteria that were linked to greater disease activity.
 

These findings suggest people with lupus have a unique oral microbiome, which could promote new methods of lupus diagnosis and monitoring. While more research is needed to fully understand the relationship between lupus and the oral microbiome, these findings will help guide future studies. Learn more about oral health issues with lupus.

 

Article Credit: Lupus Foundation of America | lupus.org

 

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COVID-19 Vaccine Response and Management in People with Lupus

A new study finds therapies used to treat lupus (mycophenolate mofetil (CellCept®), tacrolimus (Protopic®), and belimumab (Benlysta®) significantly reduce a person’s response to the COVID-19 vaccine. The COVID vaccine was most effective and did not trigger disease flares when vaccine administration was managed along with the person’s lupus medications. Some immunosuppressive drugs used to treat lupus increase COVID infection risk and decrease the vaccine’s effectiveness.

 

Researchers analyzed and compared data from 334 people with lupus and 1,887 health care workers without lupus. They examined COVID antibodyImmunoglobulin G (IgG) levels after vaccination over time in both groups. Higher IgG levels indicate a stronger immune response to the vaccine, suggesting a greater protective effect against the virus. They also looked at the effect of immunosuppressive medications on post-vaccination antibody levels in those with lupus.

 

The researchers found that taking mycophenolate mofetil, tacrolimus, and belimumab at the time of vaccination was associated with reduced IgG (COVID antibody) levels. However, temporarily stopping mycophenolate mofetil administration on the day of and for one week after the COVID vaccine resulted in increased post-vaccine IgG (COVID antibody) levels and did not lead to flare activity.

 

Researchers hope these data will be helpful to clinicians and help revise treatment guidelines for better outcomes in people with lupus. The Lupus Foundation of America remains committed to providing resources and support regarding the COVID-19 pandemic. Learn about up-to-date health information on the COVID-19 vaccine for people with lupus and talk to your doctor before making any changes to your medication.

Article Credit: Lupus Foundation of America | lupus.org

 

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New Investigational Drug for Systemic and Cutaneous Lupus Advancing to Phase I Clinical Trials

Ventus Therapeutics Inc. has announced the development of VENT-03, a potential first-in-class drug designed to target cGAS, a cell receptor linked to lupus and a broad range of other diseases including neuroinflammatory and neurodegenerative diseases. This will be the first drug of its kind to advance into clinical development, and it will enter its first Phase I trial cGAS is thought to be involved in both systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE), and the latest news marks an exciting step forward in lupus drug development.

Last year, Ventus received a Lupus Research Program Idea Award from the U.S. Department of Defense (DoD) to study the cGAS inhibitor as a potential treatment for lupus. The Lupus Foundation of America’s (LFA) advocacy efforts and strong community of advocates led the fight in establishing the DoD Lupus Research Program in 2017, successfully advocating each year for continued funding of this critical program. To date, the program has provided more than $76 million to fund high-impact, high-quality studies to help find ways to diagnose and treat lupus more effectively.

Continue to follow the LFA for updates on VENT-03 and learn more about medications used to treat lupus.

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Article Credit: Lupus Foundation of America | lupus.org

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